Identifying the fitness costs of a pyrethroid-resistant genotype in the major arboviral vector Aedes aegypti.

ABSTRACT:

Background

Effective vector control measures are essential in a world where many mosquito-borne diseases have no vaccines or drug therapies available. Insecticidal tools remain the mainstay of most vector-borne disease management programmes, although their use for both agricultural and public health purposes has resulted in selection for resistance. Despite this, little is known about the fitness costs associated with specific insecticide-resistant genotypes and their implications for the management of resistance. In Aedes aegypti, the primary vector of dengue, chikungunya, and Zika, the best-characterised resistance mechanisms are single-point mutations that protect the voltage-gated sodium channel from the action of pyrethroids.

Methods

We evaluated the fitness cost of two

SUBMITTER: Rigby LM 

PROVIDER: S-EPMC7372837 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature