EO771, the first luminal B mammary cancer cell line from C57BL/6 mice.

ABSTRACT:

Background

Despite decades of therapeutic trials, effective diagnosis, many drugs available and numerous studies on breast cancer, it remains the deadliest cancer in women. In order to choose the most appropriate treatment and to understand the prognosis of the patients, breast cancer is divided into different subtypes using a molecular classification. Just as there remains a need to discover new effective therapies, models to test them are also required.

Methods

The EO771 (also named E0771 or EO 771) murine mammary cancer cell line was originally isolated from a spontaneous tumour in C57BL/6 mouse. Although frequently used, this cell line remains poorly characterized. Therefore, the EO771 phenotype was investigated. The phenotype was compared to that of MCF-7 cells, known t

SUBMITTER: Le Naour A 

PROVIDER: S-EPMC7372867 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature