Effects of HTR1B 3' region polymorphisms and functional regions on gene expression regulation.

ABSTRACT:

Background

The HTR1B gene encodes the 5-hydroxytryptamine (5-HT1B) receptor, which is involved in a variety of brain activities and mental disorders. The regulatory effects of non-coding regions on genomic DNA are one of many reasons for the cause of genetic-related diseases. Post-transcriptional regulation that depends on the function of 3' regulatory regions plays a particularly important role. This study investigated the effects, on reporter gene expression, of several haplotypes of the HTR1B gene (rs6297, rs3827804, rs140792648, rs9361234, rs76194807, rs58138557, and rs13212041) and truncated fragments in order to analyze the function of the 3' region of HTR1B.

Results

We found that the haplotype, A-G-Del-C-T-Ins-A, enhanced the expression level compared to the main hapl

SUBMITTER: Xia X 

PROVIDER: S-EPMC7372893 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature