Dysbiosis, gut barrier dysfunction and inflammation in dementia: a pilot study.

ABSTRACT:

Background

Dementia is an increasing public health threat worldwide. The pathogenesis of dementia has not been fully elucidated yet. Inflammatory processes are hypothesized to play an important role as a driver for cognitive decline but the origin of inflammation is not clear. We hypothesize that disturbances in gut microbiome composition, gut barrier dysfunction, bacterial translocation and resulting inflammation are associated with cognitive dysfunction in dementia.

Methods

To test this hypothesis, a cohort of 23 patients with dementia and 18 age and sex matched controls without cognitive impairments were studied. Gut microbiome composition, gut barrier dysfunction, bacterial translocation and inflammation were assessed from stool and serum samples. Malnutrition was assess

SUBMITTER: Stadlbauer V 

PROVIDER: S-EPMC7372911 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature