Ontology highlight
ABSTRACT:
SUBMITTER: Kimura S
PROVIDER: S-EPMC7372932 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Kimura Shoko S Rickert Charles G CG Kojima Lisa L Aburawi Mohamed M Tanimine Naoki N Fontan Fermin F Deng Kevin K Tector Haley H Mi Lee Kang K Yeh Heidi H Markmann James F JF
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20191227 4
Through multiple mechanisms, regulatory B cells (Breg) have been shown to play an important role in the development of allograft tolerance. However, a careful understanding of the role of antigen-specificity in Breg-mediated allograft tolerance has remained elusive. In experimental models of islet and cardiac transplantation, it has been established that Bregs can be induced in vivo by anti-CD45RB ± anti-TIM1antibody treatment, resulting in prolonged, Breg-dependent allograft tolerance. The impo ...[more]