Tuberculosis following PD-1 blockade for cancer immunotherapy.

ABSTRACT: Because of the well-established therapeutic benefit of boosting antitumor responses through blockade of the T cell inhibitory receptor PD-1, it has been proposed that PD-1 blockade could also be useful in infectious disease settings, including Mycobacterium tuberculosis (Mtb) infection. However, in preclinical models, Mtb-infected PD-1^-/- mice mount exaggerated T_H1 responses that drive lethal immunopathology. Multiple cases of tuberculosis during PD-1 blockade have been observed in patients with cancer, but in humans little is understood about Mtb-specific immune responses during checkpoint blockade-associated tuberculosis. Here, we report two more cases. We describe a patient who succumbed to disseminated tuberculosis after PD-1 blockade for treatment of nasop

SUBMITTER: Barber DL 

PROVIDER: S-EPMC7372940 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature