Endocrine disrupting chemicals and COVID-19 relationships: a computational systems biology approach.

ABSTRACT: Patients at high risk of severe forms of COVID-19 frequently suffer from chronic diseases, but other risk factors may also play a role. Environmental stressors, such as endocrine disrupting chemicals (EDCs), can contribute to certain chronic diseases and might aggravate the course of COVID-19. To explore putative links between EDCs and COVID-19 severity, an integrative systems biology approach was constructed and applied. As a first step, relevant data sets were compiled from major data sources. Biological associations of major EDCs to proteins were extracted from the CompTox database. Associations between proteins and diseases known as important COVID-19 comorbidities were obtained from the GeneCards and DisGeNET databases. Based on these data, we developed a tripartite network (EDCs-prot

SUBMITTER: Wu Q 

PROVIDER: S-EPMC7373141 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature