A multiscale biophysical model for the recruitment of actin nucleating proteins at the membrane interface.

ABSTRACT: The dynamics and organization of the actin cytoskeleton are crucial to many cellular events such as motility, polarization, cell shaping, and cell division. The intracellular and extracellular signaling associated with this cytoskeletal network is communicated through cell membranes. Hence the organization of membrane macromolecules and actin filament assembly are highly interdependent. Although the actin-membrane linkage is known to happen through many routes, the major class of interactions is through the direct interaction of actin-binding proteins with the lipid class containing poly-phosphatidylinositols (PPIs). Among the PPIs, phosphatidylinositol bisphosphate (PI(4,5)P₂) acts as a significant factor controlling actin polymerization in the proximity of the membrane by bind

SUBMITTER: Fatunmbi O 

PROVIDER: S-EPMC7373224 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature