Model informed quantification of the feed-forward stimulation of growth hormone by growth hormone-releasing hormone.

ABSTRACT:

Aims

Growth hormone (GH) secretion is pulsatile and secretion varies highly between individuals. To understand and ultimately predict GH secretion, it is important to first delineate and quantify the interaction and variability in the biological processes underlying stimulated GH secretion. This study reports on the development of a population nonlinear mixed effects model for GH stimulation, incorporating individual GH kinetics and the stimulation of GH by GH-releasing hormone (GHRH).

Methods

Literature data on the systemic circulation, the median eminence, and the anterior pituitary were included as system parameters in the model. Population parameters were estimated on data from 8 healthy normal weight and 16 obese women who received a 33 μg recombinant human GH dose. The

SUBMITTER: van Esdonk MJ 

PROVIDER: S-EPMC7373696 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature