Effect of ursodeoxycholic acid on liver markers: A systematic review and meta-analysis of randomized placebo-controlled clinical trials.

ABSTRACT:

Aim

The objective of this meta-analysis was to evaluate the effect of ursodeoxycholic acid (UDCA) therapy on serum liver function tests.

Methods

PubMed, Web of Science, Scopus and Google Scholar databases were searched to identify randomized placebo-controlled trials assessing the impact of UDCA on hepatic parameters. Meta-analysis was conducted using a random-effects model and sensitivity analysis through the leave-one-out method in the Review Manager statistical software version 5.3.

Results

After UDCA treatment, meta-analysis revealed a significant reduction of alanine aminotransferase (weighted mean difference [WMD]: -15.28 U/L, 95% confidence interval [CI]: -23.42, -7.15, P = 0.0002, I² = 97%), aspartate aminotransferase (WMD: -16.13 U/L, 95% CI: -23.8

SUBMITTER: Simental-Mendia M 

PROVIDER: S-EPMC7373700 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature