Optimising the dose of clonidine to achieve sedation in intensive care unit patients with population pharmacokinetics.

ABSTRACT:

Aims

The aim of this study was to investigate the population pharmacokinetics (PK) of clonidine in intensive care unit (ICU) patients in order to develop a dosing regimen for sedation.

Methods

We included 24 adult mechanically ventilated, sedated patients from a mixed medical and surgical ICU. Intravenous clonidine was added to standard sedation in doses of 600, 1200 or 1800 μg/d. Within each treatment group, 4 patients received a loading dose of half the daily dose administered in 4 hours. Patients gave an average of 12 samples per individual. In total, 286 samples were available for analysis. Model development was conducted with NONMEM and various covariates were tested. After modelling, doses to achieve a target steady-state plasma concentration of >1.5 μg/L were explored

SUBMITTER: Cloesmeijer ME 

PROVIDER: S-EPMC7373711 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature