Precision therapy of 6-mercaptopurine in Chinese children with acute lymphoblastic leukaemia.

ABSTRACT:

Aims

Chinese children are more susceptible to the development of thiopurine-induced leukopenia compared with Caucasian populations. The aim of our study was to establish a 6-mercaptopurine (6-MP) dose-concentration-response relationship through exploration of pharmacogenetic factors involved in the thiopurine-induced toxicities in Chinese paediatric patients afflicted by acute lymphoblastic leukaemia (ALL).

Methods

Blood samples were obtained from ALL children treated with 6-MP. We determined the metabolite steady-state concentrations of 6-MP in red blood cells (RBCs) by using high-performance liquid chromatography. Pharmacogenetic analysis was carried out on patients' genomic DNA using the MassArray genotyping platform.

Results

Sixty children afflicted by ALL who rec

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC7373713 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature