Structural and Virus Regulatory Insights Into Avian N6-Methyladenosine (m6A) Machinery.

ABSTRACT: The addition of a methyl group to the N6 position of adenosine (m6A) is the most common posttranscriptional RNA modification, and it regulates most steps of RNA metabolism including splicing, stability, translation, nuclear-export, and RNA structures. Besides cellular RNA, m6A modifications have also been detected on viral RNA. A range of recent studies have demonstrated the crucial roles of m6A in the virus-host interactions; however, m6A cellular machineries are only characterized in limited mammalian species. Herein, we aim to present comprehensive evolutionary insights into major m6A writers, erasers, and readers and draw a comparative structural analysis between avian and mammalian m6A-associated machineries. The comparative collinearity on the chromosomal scale revealed that the majo

SUBMITTER: Bayoumi M 

PROVIDER: S-EPMC7373739 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature