MicroRNAs in Extracellular Vesicles in Sweat Change in Response to Endurance Exercise.

ABSTRACT:

Background

To date, microRNAs (miRs) carried in extracellular vesicles (EVs) in response to exercise have been studied in blood but not in non-invasively collectable body fluids. In the present study, we examined whether six exercise-responsive miRs, miRs-21, -26, -126, -146, -221, and -222, respond to acute endurance exercise stimuli of different intensities in sweat.

Methods

We investigated the response of miRs isolated from sweat and serum EVs to three endurance exercise protocols: (1) maximal aerobic capacity (VO_{2 max} ), (2) anaerobic threshold (AnaT), and (3) aerobic threshold (AerT) tests. Sauna bathing was used as a control test to induce sweating through increased body temperature in the absence of exercise. All protocols were performed b

SUBMITTER: Karvinen S 

PROVIDER: S-EPMC7373804 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature