Impact of plasma xanthine oxidoreductase activity in patients with heart failure with preserved ejection fraction.

ABSTRACT:

Aims

Reactive oxygen species are reportedly involved in the mechanism underlying heart failure with preserved ejection fraction (HFpEF); however, the disease pathophysiology remains poorly understood. Xanthine oxidoreductase (XOR), the rate-limiting enzyme of purine metabolism, plays an important role in uric acid production and generates reactive oxygen species. However, the impact of plasma XOR activity on the clinical outcomes of patients with HFpEF remains unclear. The aim of this study was to investigate whether plasma XOR activity is associated with major adverse cardiovascular events (MACEs) in patients with HFpEF.

Methods and results

The plasma XOR activity was measured in 257 patients with HFpEF, who were then divided into three groups according to the activity leve

SUBMITTER: Watanabe K 

PROVIDER: S-EPMC7373896 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature