Modifications of medical treatment and outcome after percutaneous correction of secondary mitral regurgitation.

ABSTRACT:

Aims

The optimization of guideline-directed medical therapy (GDMT) in reduced ejection fraction heart failure (HFrEF) is associated with improved survival and can reduce the severity of secondary mitral regurgitation (SMR). Highest tolerated doses should be achieved before percutaneous mitral valve repair (pMVR) and drugs titration further pursued after procedure. The degree of GDMT titration in patients with HFrEF and SMR treated with pMVR remains unexplored. We sought to evaluate the adherence to GDMT in HFrEF in patients undergoing pMVR and to explore the association between changes in GDMT post-pMVR and prognosis.

Methods and results

We included all the patients with HFrEF and SMR ≥ 3 + treated with pMVR between 2012 and 2019 and with available follow-up. GDMT, comprehen

SUBMITTER: Stolfo D 

PROVIDER: S-EPMC7373897 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature