Carotid arterial mechanics as useful biomarker of extracellular matrix turnover and preserved ejection fraction heart failure.

ABSTRACT:

Aims

We aimed to investigate the functional alterations, diagnostic utilization, and prognostic implication of carotid arterial deformations in subjects with cardiovascular risk factors and heart failure (HF) with preserved ejection fraction (HFpEF).

Methods and results

Among 251 prospectively participants (mean age 66.0 ± 9.8 years, 65.7% female) in a single centre between December 2011 and September 2014, carotid artery deformations including circumferential strain (CCS)/strain rate and radial strain were analysed by two-dimensional speckle tracking. We further related these carotid artery deformation indices to HF biomarkers and cardiac structure and function by echocardiography and explored their prognostic values. Significant reductions of CCS, circumferential strain ra

SUBMITTER: Zhou KN 

PROVIDER: S-EPMC7373904 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature