Familial screening in case of acute myocarditis reveals inherited arrhythmogenic left ventricular cardiomyopathies.

ABSTRACT:

Aims

Several data suggest that acute myocarditis could be related to genetic variants involved in familial cardiomyopathies, particularly arrhythmogenic cardiomyopathy, but the management of patients with acute myocarditis and their families regarding their risk for having an associated inherited cardiomyopathy is unclear.

Methods and results

Families with at least one individual with a documented episode of acute myocarditis and at least one individual with a cardiomyopathy or a history of sudden death were included in the study. Comprehensive pedigree, including genetic testing, and history of these families were analysed. Six families were included. Genetic analysis revealed a variant in desmosomal proteins genes in all the probands [five in desmoplakin (DSP) gene and one

SUBMITTER: Piriou N 

PROVIDER: S-EPMC7373927 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature