Cardiac involvement in a cross-sectional cohort of myotonic dystrophies and other skeletal myopathies.

ABSTRACT:

Aims

Cardiac involvement in myopathies that primarily affect the skeletal muscle is variable and may be subtle, necessitating sensitive diagnostic approaches. Here, we describe the prevalence of cardiac abnormalities in a cohort of patients with skeletal muscle disease presenting at a tertiary care neuromuscular centre.

Methods and results

We systematically investigated patients with skeletal myopathies and comprehensively analysed their cardiac phenotype including 24 h electrocardiogram, echocardiography with strain analyses, contrast-enhanced cardiac magnetic resonance imaging, and, if at increased risk of coronary artery disease, computed tomography coronary angiography. We prospectively screened 91 patients with diverse skeletal myopathies and enrolled 73 patients. The m

SUBMITTER: Schmid J 

PROVIDER: S-EPMC7373928 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature