Growth differentiation factor 15 in adverse cardiac remodelling: from biomarker to causal player.

ABSTRACT: Heart failure is a growing health issue as a negative consequence of improved survival upon myocardial infarction, unhealthy lifestyle, and the ageing of our population. The large and complex pathology underlying heart failure makes diagnosis and especially treatment very difficult. There is an urgent demand for discriminative biomarkers to aid disease management of heart failure. Studying cellular pathways and pathophysiological mechanisms contributing to disease initiation and progression is crucial for understanding the disease process and will aid to identification of novel biomarkers and potential therapeutic targets. Growth differentiation factor 15 (GDF15) is a proven valuable biomarker for different pathologies, including cancer, type 2 diabetes, and cardiovascular diseases. Althou

SUBMITTER: Wesseling M 

PROVIDER: S-EPMC7373942 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature