A bacterial riboswitch class senses xanthine and uric acid to regulate genes associated with purine oxidation.

ABSTRACT: Dozens of candidate orphan riboswitch classes have been discovered previously by using comparative sequence analysis algorithms to search bacterial genomic sequence databases. Each orphan is classified by the presence of distinct conserved nucleotide sequences and secondary structure features, and by its association with particular types of genes. One previously reported orphan riboswitch candidate is the "NMT1 motif," which forms a hairpin structure with an internal bulge that includes numerous highly conserved nucleotides. This motif associates with genes annotated to encode various dioxygenase enzymes, transporters, or proteins that have roles associated with thiamin or histidine metabolism. Biochemical evaluation of numerous ligand candidates revealed that NMT1 motif RNA

SUBMITTER: Yu D 

PROVIDER: S-EPMC7373994 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature