Plasma Soluble Urokinase Plasminogen Activator Receptor (suPAR) and CKD Progression in Children.

ABSTRACT:

Rationale & objective

Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker associated with incident chronic kidney disease (CKD) and has been identified as an independent risk factor for CKD progression in children, although these findings remain preliminary, limited to a single point in time, and unreplicated in pediatric cohorts.

Study design

Prospective longitudinal cohort study.

Setting & participants

565 participants aged 1 to 16 years enrolled in the Chronic Kidney Disease in Children (CKiD) Study.

Exposure

Plasma suPAR levels, categorized by quartiles, measured at study entry and a 6-month follow-up interval.

Outcome

CKD progression, defined as the initiation of kidney replacement therapy (dialysis or transplantation) or >

SUBMITTER: Weidemann DK 

PROVIDER: S-EPMC7374047 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature