Heritability and genetic correlations of obesity indices with ambulatory and office beat-to-beat blood pressure in the Oman Family Study.

ABSTRACT:

Objective

To more precisely and comprehensively estimate the genetic and environmental correlations between various indices of obesity and BP.

Methods

We estimated heritability and genetic correlations of obesity indices with BP in the Oman family study (n = 1231). Ambulatory and office beat-to-beat BP was measured and mean values for SBP and DBP during daytime, sleep, 24-h and 10 min at rest were calculated. Different indices were used to quantify obesity and fat distribution: BMI, percentage of body fat (%BF), waist circumference and waist-to-height ratio (WHtR). SOLAR software was used to perform univariate and bivariate quantitative genetic analyses adjusting for age, age, sex, age-sex and age--sex interactions.

Results

Heritabilities of BP ranged from 30.2 to 38.

SUBMITTER: Man T 

PROVIDER: S-EPMC7374053 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature