Characterization of colorectal mucus using infrared spectroscopy: a potential target for bowel cancer screening and diagnosis.

ABSTRACT: Biological materials presenting early signs of cancer would be beneficial for cancer screening/diagnosis. In this respect, the suitability of potentially exploiting mucus in colorectal cancer was tested using infrared spectroscopy in combination with statistical modeling. Twenty-six paraffinized colon tissue biopsy sections containing mucus regions from 20 individuals (10 normal and 16 cancerous) were measured using mid-infrared spectroscopic imaging. A digital de-paraffinization, followed by cluster analysis driven digital color-coded multi-staining segmented the infrared images into various histopathological features such as epithelium, connective tissue, stroma, and mucus regions within the tissue sections. Principal component analysis followed by supervised linear discriminant analysis

SUBMITTER: Nallala J 

PROVIDER: S-EPMC7374084 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature