Lactate concentration in breast cancer using advanced magnetic resonance spectroscopy.

ABSTRACT:

Background

Precision medicine in breast cancer demands markers sensitive to early treatment response. Aerobic glycolysis (AG) upregulates lactate dehydrogenase A (LDH-A) with elevated lactate production; however, existing approaches for lactate quantification are either invasive or impractical clinically.

Methods

Thirty female patients (age 39-78 years, 15 grade II and 15 grade III) with invasive ductal carcinoma were enrolled. Lactate concentration was quantified from freshly excised whole tumours with double quantum filtered (DQF) magnetic resonance spectroscopy (MRS), and Nottingham Prognostic Index (NPI), LDH-A and proliferative marker Ki-67 were assessed histologically.

Results

There was a significantly higher lactate concentration (t = 2.2224, p = 0.0349) in gra

SUBMITTER: Cheung SM 

PROVIDER: S-EPMC7374160 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature