Association of Tooth Loss with New-Onset Parkinson's Disease: A Nationwide Population-Based Cohort Study.

ABSTRACT:

Introduction

Tooth loss is associated with poor oral hygiene. During insufficient oral sanitation, focal infection and inflammation can occur and these reactions may induce systemic inflammation. Systemic inflammatory reaction may be related to the degeneration of dopamine neurons in the substantia nigra. We hypothesized that tooth loss is related to increased risk of new-onset Parkinson's disease.

Methods

Between 2003 and 2006, we included 153,165 participants from the national health insurance system-health screening cohort in Korea. The incidence of new-onset Parkinson's disease was defined as International Classification of Diseases-10 code "G20," accompanying the prescription records for any anti-Parkinson's disease medication.

Results

Approximately 19.9% of the

SUBMITTER: Woo HG 

PROVIDER: S-EPMC7374233 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature