Atomic Force Microscopy Imaging in Turbid Liquids: A Promising Tool in Nanomedicine.

ABSTRACT: Tracking of biological and physiological processes on the nanoscale is a central part of the growing field of nanomedicine. Although atomic force microscopy (AFM) is one of the most appropriate techniques in this area, investigations in non-transparent fluids such as human blood are not possible with conventional AFMs due to limitations caused by the optical readout. Here, we show a promising approach based on self-sensing cantilevers (SSC) as a replacement for optical readout in biological AFM imaging. Piezo-resistors, in the form of a Wheatstone bridge, are embedded into the cantilever, whereas two of them are placed at the bending edge. This enables the deflection of the cantilever to be precisely recorded by measuring the changes in resistance. Furthermore, the conventional acoustic or

SUBMITTER: Leitner M 

PROVIDER: S-EPMC7374447 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature