Sex Differences in Internalizing Symptoms and Amygdala Functional Connectivity in Neurotypical Youth.

ABSTRACT: Amygdala resting-state functional connectivity (rsFC) is altered in adolescents with internalizing disorders, though the relationship between rsFC and subclinical symptomatology in neurotypical youth remains unclear. Here we examined whether amygdala rsFC varied across a continuum of internalizing symptoms in 110 typically-developing (TD) youths 8 to 17 years old using functional magnetic resonance imaging (fMRI). We assessed overall internalizing symptoms, as well as anxious-depressed, withdrawn-depressed, and somatic complaints. Given known sex differences in the prevalence of internalizing disorders, we compared connectivity between males and females. As compared to males, females with greater internalizing, anxious-depressed, and somatic symptoms displayed greater connectivity with the

SUBMITTER: Padgaonkar NT 

PROVIDER: S-EPMC7374605 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature