A systematic review and narrative synthesis of data-driven studies in schizophrenia symptoms and cognitive deficits.

ABSTRACT: To tackle the phenotypic heterogeneity of schizophrenia, data-driven methods are often applied to identify subtypes of its symptoms and cognitive deficits. However, a systematic review on this topic is lacking. The objective of this review was to summarize the evidence obtained from longitudinal and cross-sectional data-driven studies in positive and negative symptoms and cognitive deficits in patients with schizophrenia spectrum disorders, their unaffected siblings and healthy controls or individuals from general population. Additionally, we aimed to highlight methodological gaps across studies and point out future directions to optimize the translatability of evidence from data-driven studies. A systematic review was performed through searching PsycINFO, PubMed, PsycTESTS, PsycARTICLES,

SUBMITTER: Habtewold TD 

PROVIDER: S-EPMC7374614 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature