Enrichment of the tumour immune microenvironment in patients with desmoplastic colorectal liver metastasis.

ABSTRACT:

Background

Patients with resected colorectal liver metastasis (CRLM) who display only the desmoplastic histopathological growth pattern (dHGP) exhibit superior survival compared to patients with any non-desmoplastic growth (non-dHGP). The aim of this study was to compare the tumour microenvironment between dHGP and non-dHGP.

Methods

The tumour microenvironment was investigated in three cohorts of chemo-naive patients surgically treated for CRLM. In cohort A semi-quantitative immunohistochemistry was performed, in cohort B intratumoural and peritumoural T cells were counted using immunohistochemistry and digital image analysis, and in cohort C the relative proportions of individual T cell subsets were determined by flow cytometry.

Results

One hundred and seventeen, 34,

SUBMITTER: Hoppener DJ 

PROVIDER: S-EPMC7374625 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature