ATP-powered molecular recognition to engineer transient multivalency and self-sorting 4D hierarchical systems.

ABSTRACT: Biological systems organize multiple hierarchical structures in parallel, and create dynamic assemblies and functions by energy dissipation. In contrast, emerging artificial non-equilibrium self-assembling systems have remained relatively simplistic concerning hierarchical design, and non-equilibrium multi-component systems are uncharted territory. Here we report a modular DNA toolbox allowing to program transient non-equilibrium multicomponent systems across hierarchical length scales by introducing chemically fueled molecular recognition orchestrated by reaction networks of concurrent ATP-powered ligation and cleavage of freely programmable DNA building blocks. Going across hierarchical levels, we demonstrate transient side-chain functionalized nucleic acid polymers, and further introduc

SUBMITTER: Deng J 

PROVIDER: S-EPMC7374688 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature