Ontology highlight
ABSTRACT:
SUBMITTER: Bernier M
PROVIDER: S-EPMC7374720 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
NPJ aging and mechanisms of disease 20200721
There is an unmet need and urgency to find safe and effective anti-obesity interventions. Our recent study in mice fed on obesogenic diet found that treatment with the alcohol aversive drug disulfiram reduced feeding efficiency and led to a decrease in body weight and an increase in energy expenditure. The intervention with disulfiram improved glucose tolerance and insulin sensitivity, and mitigated metabolic dysfunctions in various organs through poorly defined mechanisms. Here, integrated anal ...[more]