Defining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site.

ABSTRACT:

Background

The binding of HIV-1 Envelope glycoproteins (Env) to host receptor CD4 exposes vulnerable conserved epitopes within the co-receptor binding site (CoRBS) which are required for the engagement of either CCR5 or CXCR4 co-receptor to allow HIV-1 entry. Antibodies against this region have been implicated in the protection against HIV acquisition in non-human primate (NHP) challenge studies and found to act synergistically with antibodies of other specificities to deliver effective Fc-mediated effector function against HIV-1-infected cells. Here, we describe the structure and function of N12-i2, an antibody isolated from an HIV-1-infected individual, and show how the unique structural features of this antibody allow for its effective Env recognition and Fc-mediated effector fu

SUBMITTER: Tolbert WD 

PROVIDER: S-EPMC7374964 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature