A novel immunocompetent model of metastatic prostate cancer-induced bone pain.

ABSTRACT:

Background

Over 70% to 85% of men with advanced prostate cancer (PCa) develop bone metastases characterized by severe bone pain and increased likelihood of bone fracture. These clinical features result in decreased quality of life and act as a predictor of higher mortality. Mechanistically, the skeletal pathologies such as osteolytic lesions and abnormal osteoblastic activity drive these symptoms. The role of immune cells in bone cancer pain remains understudied, here we sought to recapitulate this symptomology in a murine model.

Methods

The prostate cancer bone metastasis-induced pain model (CIBP) was established by transplanting a mouse prostate cancer cell line into the femur of immunocompetent mice. Pain development, gait dynamics, and the changes in emotional activities

SUBMITTER: Liu Z 

PROVIDER: S-EPMC7375026 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature