Partitioning heritability analyses unveil the genetic architecture of human brain multidimensional functional connectivity patterns.

ABSTRACT: Resting-state functional connectivity profiles have been increasingly shown to be important endophenotypes that are tightly linked to human cognitive functions and psychiatric diseases, yet the genetic architecture of this multidimensional trait is barely understood. Using a unique sample of 1,704 unrelated, young and healthy Chinese Han individuals, we revealed a significant heritability of functional connectivity patterns in the whole brain and several subnetworks. We further proposed a partitioned heritability analysis for multidimensional functional connectivity patterns, which revealed the common and unique enrichment patterns of the genetic contributions to brain connectivity patterns for several gene sets linked to brain functions, including the genes expressed preferentially in the

SUBMITTER: Feng J 

PROVIDER: S-EPMC7375050 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature