The association of COMT genotype with buproprion treatment response in the treatment of major depressive disorder.

ABSTRACT:

Background

Pharmacodynamics and pharmacogenetics are being explored in pharmacological treatment response for major depressive disorder (MDD). Interactions between genotype and treatment response may be dose dependent. In this study, we examined whether MDD patients with Met/Met, Met/Val, and Val/Val COMT genotypes differed in their response to bupropion in terms of depression scores.

Methods

This study utilized a convenience sample of 241 adult outpatients (≥18 years) who met DSM-5 criteria for MDD and had visits at a Midwest psychopharmacology clinic between February 2016 and January 2017. Exclusion criteria included various comorbid medical, neurological, and psychiatric conditions and current use of benzodiazepines or narcotics. Participants completed genetic testing and

SUBMITTER: Fawver J 

PROVIDER: S-EPMC7375060 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature