Brain substrate metabolism and ß-cell function in humans: A positron emission tomography study.

ABSTRACT:

Aims

Recent clinical studies have shown enhanced brain glucose uptake during clamp and brain fatty acid uptake in insulin-resistant individuals. Preclinical studies suggest that the brain may be involved in the control of insulin secretion. The aim of this study was to investigate whether brain metabolism assessed as brain glucose and fatty acid uptake is associated with the parameters of β-cell function in humans.

Materials and methods

We analysed cross-sectional data of 120 subjects across a wide range of BMI and insulin sensitivity. Brain glucose uptake (BGU) was measured during euglycaemic-hyperinsulinaemic clamp (n = 67) and/or during fasting (n = 45) using [¹⁸F]-fluorodeoxyglucose (FDG) positron emission tomography (PET). In another group of subjects (n = 34

SUBMITTER: Rebelos E 

PROVIDER: S-EPMC7375082 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature