Alterations of local functional connectivity in lifespan: A resting-state fMRI study.

ABSTRACT:

Introduction

As aging attracted attention globally, revealing changes in brain function across the lifespan was largely concerned. In this study, we aimed to reveal the changes of functional networks of the brain (via local functional connectivity, local FC) in lifespan and explore the mechanism underlying them.

Materials and methods

A total of 523 healthy participants (258 males and 265 females) aged 18-88 years from part of the Cambridge Center for Ageing and Neuroscience (CamCAN) were involved in this study. Next, two data-driven measures of local FC, local functional connectivity density (lFCD) and four-dimensional spatial-temporal consistency of local neural activity (FOCA), were calculated, and then, general linear models were used to assess the changes of them in life

SUBMITTER: Wen X 

PROVIDER: S-EPMC7375100 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature