Performance of the Rule of 5 for Detecting Glaucoma Progression between Visits with OCT.

ABSTRACT:

Purpose

To evaluate whether loss of 5 μm or more in global retinal nerve fiber layer (RNFL) thickness on spectral-domain (SD) between 2 consecutive visits is specific for glaucoma progression.

Design

Prospective cohort.

Participants

Ninety-two eyes of 49 control participants and 300 eyes of 210 glaucoma patients.

Methods

Patients completed at least 5 standard automated perimetry and SD OCT examinations at 6-month intervals over at least 2 years. Eyes were categorized as progressing from glaucoma if the average RNFL declined by 5 μm or more between 2 consecutive visits. The false-positive proportion was estimated by 2 methods: (1) 5-μm or more loss in control participants and (2) 5-μm or more gain in glaucoma. The false-positive proportion was subtracted from th

SUBMITTER: Thompson AC 

PROVIDER: S-EPMC7375168 | biostudies-literature | 2019 Sep - Oct

REPOSITORIES: biostudies-literature