Y-Chromosome Variation in Southern African Khoe-San Populations Based on Whole-Genome Sequences.

ABSTRACT: Although the human Y chromosome has effectively shown utility in uncovering facets of human evolution and population histories, the ascertainment bias present in early Y-chromosome variant data sets limited the accuracy of diversity and TMRCA estimates obtained from them. The advent of next-generation sequencing, however, has removed this bias and allowed for the discovery of thousands of new variants for use in improving the Y-chromosome phylogeny and computing estimates that are more accurate. Here, we describe the high-coverage sequencing of the whole Y chromosome in a data set of 19 male Khoe-San individuals in comparison with existing whole Y-chromosome sequence data. Due to the increased resolution, we potentially resolve the source of haplogroup B-P70 in the Khoe-San, and reconcile

SUBMITTER: Naidoo T 

PROVIDER: S-EPMC7375190 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature