SGCE Promotes Breast Cancer Stem Cells by Stabilizing EGFR.

ABSTRACT: Breast cancer stem cells (BCSCs) are responsible for resistance to chemotherapy, high degree of metastasis, and poor prognosis, especially in triple-negative breast cancer (TNBC). The CD24^lowCD44^high and high aldehyde dehydrogenase 1 (ALDH1) cell subpopulation (CD24^lowCD44^high ALDH1⁺) exhibit very high tumor initiating capacity. In the current study, the upregulated genes are analyzed in both CD24^lowCD44^high and ALDH1⁺ cell populations at single-cell resolution, and a highly expressed membrane protein, SGCE, is identified in both BCSC populations. Further results show that SGCE depletion reduces BCSC self-renewal, chemoresistance, and metastasis both in vitro and in vivo, partially through affecting the

SUBMITTER: Zhao L 

PROVIDER: S-EPMC7375232 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature