Ovarian Cancer Chemoresistance Relies on the Stem Cell Reprogramming Factor PBX1.

ABSTRACT: The evolution of chemoresistance is a fundamental characteristic of cancer that ultimately hampers its clinical management. However, it may be possible to improve patient outcomes significantly by a better understanding of resistance mechanisms, which cancers rely upon during the evolution to an untreatable state. Here we report an essential role of the stem cell reprogramming factor, PBX1, in mediating chemoresistance in ovarian carcinomas. In the clinical setting, high levels of PBX1 expression correlated with shorter survival in post-chemotherapy ovarian cancer patients. In tumor cells with low endogenous levels of PBX1, its enforced expression promoted cancer stem cell-like phenotypes, including most notably an increase in resistance to platinum-based therapy used most commonly for tre

SUBMITTER: Jung JG 

PROVIDER: S-EPMC7375390 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature