M1^hot tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer.

ABSTRACT:

Background

The role of tumor-associated macrophages (TAMs) in determining the outcome between the antitumor effects of the adaptive immune system and the tumor's anti-immunity stratagems, is controversial. Macrophages modulate their activities and phenotypes by integration of signals in the tumor microenvironment. Depending on how macrophages are activated, they may adopt so-called M1-like, antitumor or M2-like, protumor profiles. In many solid tumors, a dominance of M2-like macrophages is associated with poor outcomes but in some tumor types, strong M1-like profiles are linked to better outcomes. We aimed to investigate the interrelationship of these TAM populations to establish how they modulate the efficacy of the adaptive immune system in early lung cancer.

Methods

Macro

SUBMITTER: Garrido-Martin EM 

PROVIDER: S-EPMC7375465 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature