Mammographic density changes during neoadjuvant breast cancer treatment: NeoDense, a prospective study in Sweden.

ABSTRACT:

Objectives

To assess if mammographic density (MD) changes during neoadjuvant breast cancer treatment and is predictive of a pathological complete response (pCR).

Methods

We prospectively included 200 breast cancer patients assigned to neoadjuvant chemotherapy (NACT) in the NeoDense study (2014-2019). Raw data mammograms were used to assess MD with a fully automated volumetric method and radiologists categorized MD using the Breast Imaging-Reporting and Data System (BI-RADS), 5th Edition. Logistic regression was used to calculate odds ratios (OR) for pCR comparing BI-RADS categories c vs. a, b, and d as well as with a 0.5% change in percent dense volume adjusting for baseline characteristics.

Results

The overall median age was 53.1 years, and 48% of study participants

SUBMITTER: Skarping I 

PROVIDER: S-EPMC7375568 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature