Clinical and genetic risk factors for aromatase inhibitor-associated arthralgia in breast cancer survivors.

ABSTRACT:

Background

Arthralgia is a common and debilitating toxicity of aromatase inhibitors (AI) that leads to premature drug discontinuation. We sought to evaluate the clinical and genetic risk factors associated with AI-associated arthralgia (AIAA).

Methods

We performed a cross-sectional study among postmenopausal women with stage 0-III breast cancer who were prescribed a third-generation AI for adjuvant therapy. The primary outcome was patient-reported AIAA occurrence. We extracted and assayed germline DNA for single nucleotide polymorphisms (SNPs) of genes implicated in estrogen and inflammation pathways. Multivariable logistic regression models examined the association between demographic, clinical, and genetic factors and AIAA. Analyses were restricted to White participants.

SUBMITTER: Romero SAD 

PROVIDER: S-EPMC7375589 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature