Prophylactic Use of Enoxaparin in Adolescents During Bariatric Surgery-a Prospective Clinical Study.

ABSTRACT:

Introduction

Severe obesity predisposes youth to a higher risk of venous thromboembolism (VTE). This study evaluates a BMI-stratified prophylactic dosing regimen of enoxaparin in adolescents with severe obesity undergoing surgery.

Methods

Adolescents aged 12-20 years received prophylactic enoxaparin at 40 mg SC (for a BMI < 50 kg/m²) and 60 mg SC (for a BMI ≥ 50 kg/m²) every 12 h until discharge. Blood samples were drawn at pre-dose, 1, 2, 4, 6, and 12 h. Plasma Anti-Factor Xa (Anti-FXa) activity was used as a surrogate marker for enoxaparin pharmacokinetics.

Results

Ten female and two male obese adolescents (age range 14-19 years) had a mean BMI of 49.9 kg/m² (38.4-58 kg/m²). Four patients had a BMI of less than 50 kg/m

SUBMITTER: Vaughns JD 

PROVIDER: S-EPMC7375856 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature