Derivation of a measure of physiological multisystem dysregulation: Results from WHAS and health ABC.

ABSTRACT:

Introduction

Multifactorial biological processes underpin dysregulation over several individual physiological systems. However, it is challenging to characterize and model this multisystemic dysregulation and its relationship with individual physiologic systems. We operationalized a theory-driven measure of multisystem dysregulation and empirically tested for measurement differences by key characteristics.

Methods

We used the Women's Health and Aging Studies (WHAS) I and II (N = 649), and the Health ABC study (N = 1515). Twelve biomarkers representing multiple systems including stress response (e.g., inflammation), endocrine system, and energy regulation were identified. A series of confirmatory factor analyses (CFA) were conducted to evaluate the interplay between physiolog

SUBMITTER: Gross AL 

PROVIDER: S-EPMC7375911 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature