Arp2/3 and Mena/VASP Require Profilin 1 for Actin Network Assembly at the Leading Edge.

ABSTRACT: Cells have many types of actin structures, which must assemble from a common monomer pool. Yet, it remains poorly understood how monomers are distributed to and shared between different filament networks. Simplified model systems suggest that monomers are limited and heterogeneous, which alters actin network assembly through biased polymerization and internetwork competition. However, less is known about how monomers influence complex actin structures, where different networks competing for monomers overlap and are functionally interdependent. One example is the leading edge of migrating cells, which contains filament networks generated by multiple assembly factors. The leading edge dynamically switches between the formation of different actin structures, such as lamellipodia or filopodia,

SUBMITTER: Skruber K 

PROVIDER: S-EPMC7375932 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature