Identification of a Human Skin Commensal Bacterium that Selectively Kills Cutibacterium acnes.

ABSTRACT: The microbiome represents a vast resource for drug discovery, as its members engage in constant conflict to outcompete one another by deploying diverse strategies for survival. Cutibacterium acnes is one of the most common bacterial species on human skin and can promote the common disease acne vulgaris. By employing a combined strategy of functional screening, genetics, and proteomics we discovered a strain of Staphylococcus capitis (S. capitis E12) that selectively inhibited growth of C. acnes with potency greater than antibiotics commonly used in the treatment of acne. Antimicrobial peptides secreted from S. capitis E12 were identified as four distinct phenol-soluble modulins acting synergistically. These peptides were not toxic to human keratinocytes and the S. capitis extract did not k

SUBMITTER: O'Neill AM 

PROVIDER: S-EPMC7375939 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature