Time trends in pregnancy-related outcomes among women with type 1 diabetes mellitus, 2004-2017.
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ABSTRACT: Objective
To examine time trends in US pregnant women with type 1 diabetes mellitus for maternal characteristics and pregnancy outcomes.Study design
We abstracted clinical data from the medical records of 700 pregnant women from 2004 to 2017. For each time period, means and percentages were calculated. P values for trend were calculated using linear and logistic regression.Results
HbA1c in each trimester was unchanged across the analysis period. The prevalence of nephropathy decreased from 4.8% to 0% (P = 0.002). Excessive gestational weight gain increased (P = 0.01). Gestation length also increased (P = 0.01), as did vaginal deliveries (P = 0.03). There were no change in birthweight over time (P = 0.07) and the percentage of neonates with macrosomia and large for gestational age (LGA) neonates also remained unchanged.Conclusion
Obstetric guideline changes may have improved gestation length and mode of delivery; however, other outcomes need more attention, including excessive gestational weight gain, macrosomia, and LGA.
SUBMITTER: Helman S
PROVIDER: S-EPMC7375951 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Time trends in pregnancy-related outcomes among women with type 1 diabetes mellitus, 2004-2017.
Helman Sarit S James-Todd Tamarra M TM Wang Zifan Z Bellavia Andrea A Wyckoff Jennifer A JA Serdy Shanti S Halprin Elizabeth E O'Brien Karen K Takoudes Tamara T Gupta Munish M McElrath Thomas F TF Brown Florence M FM
Journal of perinatology : official journal of the California Perinatal Association 20200602 8
<h4>Objective</h4>To examine time trends in US pregnant women with type 1 diabetes mellitus for maternal characteristics and pregnancy outcomes.<h4>Study design</h4>We abstracted clinical data from the medical records of 700 pregnant women from 2004 to 2017. For each time period, means and percentages were calculated. P values for trend were calculated using linear and logistic regression.<h4>Results</h4>HbA1c in each trimester was unchanged across the analysis period. The prevalence of nephropa ...[more]
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